A robotic shoulder could make it easier to grow usable human tissue

But the growing number of useful human tendon cells જરૂર which need to be stretched and twisted has proved more difficult. Over the past two decades, scientists have encouraged engineered tendon cells and tissues to grow and mature by repeatedly pulling in one direction. However, this approach has so far failed to create fully functional tissue grafts that can be used medically in the human body.

A new study published today in Nature Communication Engineering shows how humanoid robots can be used to create engineered tendon tissue that looks like the real thing.

“The clinical need is clearly there,” says Pierre-Alexis Mouthu of Oxford University, who led the team. “If we can make grafts in vitro that are of good quality enough to be used in clinics, it will be really helpful in improving the results in patients. Any improvement would be more than welcome. “

The first step involves redesigning the test chamber containing the cells, known as bioreactors, to attach them to the human robotic shoulder, which can twist, push, pull, and twist the cells, like musculoskeletal tissue.

While conventional bioreactors are like rigid boxes, the team created a flexible one in which human fibroblast cells વિસ્ત the elongated cells found in connective tissue-are grown on a soft plastic scaffold hanging between two rigid blocks. They attached the chamber to a robotic shoulder that spends more than 14 days and a half hours mimicking the type of upbringing and rotation that humans do.

Later, bioreactor cells were found to reproduce faster than specimens that were not stretched, and they expressed genes differently જોકે although researchers do not yet know how that will translate into graft quality. The team plans to investigate how cells grown in their new bioreactors compare to cells grown in traditional stretch bioreactors.

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